Creatine is a nitrogen-containing compound derived from reactions involving the amino acids arginine, glycine and methionine in the liver and brain. Though derived from amino acids, creatine itself is technically not one of the 20 amino acids that are the building blocks of all proteins.

Alternatively, creatine can be consumed in the diet, and is primarily found in animal-based foods like red meat, poultry and seafood, or through commercially manufactured supplement products containing chemically synthesized creatine monohydrate. 

While skeletal muscle does not synthesize creatine, it stores approximately 95% of the body's total creatine, with the remaining 5% stored in other tissues such as the brain and bone. 

Inside the cell, creatine becomes bound to phosphate and is stored as phosphocreatine. 

It is phosphocreatine that plays the pivotal role in the maintenance, optimization and regeneration of the ATP (adenosine triphosphate), the mitochondrial energy currency of your cells, especially during periods of physical and mental activity. 

Acting like a rapid recharge system, it enables harder training, faster recovery, and prolonged peak brain performance, whether in the gym, the office, or life.

reatine is one of the safest, most studied supplements on the market:

• Daily doses of 3-5 grams are safe for healthy adults.

• It poses no harm to the kidneys or liver.

• Creatine is not a steroid, nor does it cause male pattern baldness.

• Over 680 clinical studies confirm its safety for all ages.

Creatine’s biggest benefits show up over time.

Weeks 1 to 2

• Your muscles and brain are building up creatine stores.

• Some subtle changes like slightly less fatigue, improved mental clarity, and less of a crash after strenuous efforts.

Weeks 3 to 4

• A little more strength when lifting.

• Better recovery from exercise.

• A more stable sense of energy upon waking.

+Month 2

• Noticeable improvement in strength, power, and muscle definition.

• Less mental fatigue.

• Deep, lasting all-day energy.

Adopted on February 17th, 2004: Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food, on a request from the commission related to creatine monohydrate for use in foods for particular nutritional uses. View  →

Adopted on June 30th, 2011: Creatine and increase in physical performance during short-term, high-intensity, repeated exercise bouts, increase in endurance capacity, and increase in endurance performance. View →

Adopted on February 2nd, 2016: Creatine in combination with resistance training and improvement in muscle strength. View →

Ruling confirmation on May 30th, 2023: Member European States came to a binding determination that creatine monohydrate is not a novel food, meaning it may be used regularly in food products throughout the EU. View  →

Approved on March 5th, 2020: FDA classified creatine monohydrate as GRAS (Generally Recognized as Safe), which means it can be used as a food and beverage ingredient without special approval.

Intended Use: Ingredient in energy drinks, protein bars and powders, milk shakes, meal replacement bars and powders, meat analogs, and dry powdered drink mixes at a level of 1.2 grams (g)/serving (equivalent to 1.0 g creatine/ serving). View →

our consumers want more than performance, they want energy, cognitive support, and overall health.

• Enhanced athletic performance: More strength, power, and quicker recovery.

• Cognitive benefits: Better memory, attention, and mental endurance.

• Cardiovascular support: Increased energy production, improved oxygen efficiency, and hydration during exercise.

• Age-related health: Combats muscle loss, supports brain health and improves bone density.

Creatine supports anyone looking to improve muscle mass, cognitive function, cardiovascular fitness, or overall vitality.

Who might be hesitant to consume it due to the current extent of scientific research?

• Pregnant or breastfeeding women

• Children

Emerging research explores creatine’s role in conditions like dementia, muscular dystrophy, and rehabilitation, highlighting its promise beyond sports.

• Some may experience mild stomach discomfort during loading phases.

• Staying well-hydrated is crucial.

Until today, creatine’s stability in liquid or moisture-rich formats has been a challenge due to its natural degradation into creatinine. Jenerise delivers breakthrough technology and innovative solutions that overcome this barrier, enabling creatine to be effectively added into ready-to-drink (RTD), ready-to-mix (RTM), and ready-to-eat (RTE) product formats without compromising efficacy or shelf life.

Creatine monohydrate is synthesized by combining sarcosinate (N-methylglycinate) and cyanamide under heat and pressure in a controlled reactor. This process produces pure creatine crystals, which are carefully purified, dried, and milled into a fine mesh powder to optimize solubility and performance.

With thousands of scientific publications backing creatine’s benefits, Jenerise helps you access high-quality creatine monohydrate, paired with expert liquid stable formulation support and regulatory guidance to ensure you get the right ingredient, in the right format, to meet your customers’ evolving needs and bring your product vision to life.

This positions your brand at the forefront of functional ingredient trends while satisfying consumer demand for transparent, effective products.